Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 cst l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2680558	0.1348002	0.0599408
Weighted median	23	0.1673014	0.0573404	0.0035264
Inverse variance weighted	23	0.2090077	0.0517475	0.0000537
Simple mode	23	0.1713648	0.0975090	0.0927541
Weighted mode	23	0.1667425	0.0638598	0.0159492

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.86819	21	0.0133545
Inverse variance weighted	38.27657	22	0.0170548

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036259	0.0076192	0.6390665

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0020197	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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