Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 cgh r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1252104	0.1003847	0.2260170
Weighted median	23	0.1935696	0.0567231	0.0006436
Inverse variance weighted	23	0.1593575	0.0392320	0.0000487
Simple mode	23	0.2108365	0.0923379	0.0324311
Weighted mode	23	0.1894671	0.0659614	0.0088479

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.21548	21	0.5713194
Inverse variance weighted	19.35205	22	0.6235003

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0020968	0.0056739	0.7154153

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010864	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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