Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 cgh l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2034205	0.1003855	0.0556129
Weighted median	23	0.1613195	0.0528876	0.0022867
Inverse variance weighted	23	0.1282266	0.0392322	0.0010816
Simple mode	23	0.1923453	0.0882196	0.0402151
Weighted mode	23	0.1825877	0.0632482	0.0085599

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.09390	21	0.9609268
Inverse variance weighted	11.75613	22	0.9622129

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0046173	0.005674	0.4249077

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006799	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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