Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 cgc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3016777	0.1518244	0.0601211
Weighted median	23	0.1267379	0.0631133	0.0446324
Inverse variance weighted	23	0.1642096	0.0592912	0.0056135
Simple mode	23	0.0838354	0.1076887	0.4445684
Weighted mode	23	0.0986900	0.0775253	0.2163051

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.03674	21	0.0006798
Inverse variance weighted	50.25012	22	0.0005425

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0084413	0.0085815	0.3364744

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.002053	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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