Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 cgc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1416423	0.1307179	0.2908393
Weighted median	23	0.0972427	0.0611508	0.1117868
Inverse variance weighted	23	0.1536546	0.0499234	0.0020853
Simple mode	23	0.1660256	0.1057275	0.1306139
Weighted mode	23	0.0783203	0.0721377	0.2893634

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.60745	21	0.0241907
Inverse variance weighted	35.62435	22	0.0333011

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007376	0.0073884	0.9214223

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015441	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8