Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 atr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2947606	0.1313167	0.0356909
Weighted median	23	0.1571969	0.0569640	0.0057875
Inverse variance weighted	23	0.2066793	0.0507697	0.0000468
Simple mode	23	0.1608928	0.0906296	0.0896895
Weighted mode	23	0.1572776	0.0641365	0.0225981

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.93539	21	0.0222334
Inverse variance weighted	36.84406	22	0.0246047

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0054087	0.0074223	0.4742295

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019567	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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