Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 atr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2435158	0.1069433	0.0333646
Weighted median	23	0.2014285	0.0564693	0.0003610
Inverse variance weighted	23	0.1954789	0.0410645	0.0000019
Simple mode	23	0.2154471	0.0921224	0.0288406
Weighted mode	23	0.2064585	0.0705800	0.0078386

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.83326	21	0.3012073
Inverse variance weighted	24.10353	22	0.3418262

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0029497	0.0060446	0.630613

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014825	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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