Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 ar r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2269652	0.1542739	0.1560685
Weighted median	23	0.1393613	0.0594867	0.0191432
Inverse variance weighted	23	0.2109572	0.0589231	0.0003433
Simple mode	23	0.1796457	0.1059920	0.1042048
Weighted mode	23	0.1148507	0.0651151	0.0916482

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	49.59819	21	0.0004148
Inverse variance weighted	49.62820	22	0.0006582

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.000983	0.0087198	0.911316

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0023791	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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