Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 ar l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2419662	0.1400296	0.0986733
Weighted median	23	0.1365938	0.0619786	0.0275324
Inverse variance weighted	23	0.2100622	0.0535451	0.0000874
Simple mode	23	0.2612630	0.1199170	0.0403484
Weighted mode	23	0.1544463	0.0687819	0.0351164

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.86253	21	0.0058307
Inverse variance weighted	40.98175	22	0.0082824

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0019591	0.0079148	0.8069077

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0021103	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8