Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 unc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2199377	0.1389003	0.1282702
Weighted median	23	0.1966730	0.0587263	0.0008111
Inverse variance weighted	23	0.2581645	0.0531480	0.0000012
Simple mode	23	0.1340243	0.0840618	0.1251232
Weighted mode	23	0.1678184	0.0603716	0.0109258

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.20589	21	0.0070195
Inverse variance weighted	40.37704	22	0.0097655

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023473	0.0078509	0.7678881

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0025351	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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