Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 unc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2245267	0.1372820	0.1168427
Weighted median	23	0.1657365	0.0575813	0.0039982
Inverse variance weighted	23	0.2168169	0.0524218	0.0000353
Simple mode	23	0.1628942	0.0825445	0.0611407
Weighted mode	23	0.1510589	0.0617602	0.0229106

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.27387	21	0.0091015
Inverse variance weighted	39.28083	22	0.0131017

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004734	0.0077595	0.9519263

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.002115	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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