Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 str r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2101696	0.1802066	0.2565800
Weighted median	23	0.1217816	0.0647873	0.0601469
Inverse variance weighted	23	0.1906243	0.0688298	0.0056142
Simple mode	23	0.0902329	0.1230717	0.4711937
Weighted mode	23	0.0798031	0.0626180	0.2158037

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	67.67469	21	8.0e-07
Inverse variance weighted	67.71944	22	1.5e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012002	0.0101856	0.9073209

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0027665	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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