Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 str l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2768707	0.1576751	0.0936721
Weighted median	23	0.1989267	0.0635211	0.0017382
Inverse variance weighted	23	0.2213023	0.0604141	0.0002492
Simple mode	23	0.1593715	0.0965818	0.1131244
Weighted mode	23	0.1787593	0.0770658	0.0300377

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	51.81126	21	0.0002031
Inverse variance weighted	52.17293	22	0.0002959

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034122	0.0089122	0.705662

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0025439	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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