Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 slf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2147217	0.1942146	0.2814099
Weighted median	23	0.1998318	0.0614857	0.0011538
Inverse variance weighted	23	0.2561223	0.0742493	0.0005616
Simple mode	23	0.2777221	0.1038861	0.0138838
Weighted mode	23	0.1697980	0.0560213	0.0061375

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	78.60677	21	0
Inverse variance weighted	78.80753	22	0

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0025422	0.0109774	0.8191012

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0036769	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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