Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 ptr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3376232	0.1273004	0.0149054
Weighted median	23	0.2068433	0.0547241	0.0001570
Inverse variance weighted	23	0.1868640	0.0504861	0.0002145
Simple mode	23	0.2382650	0.0989696	0.0248935
Weighted mode	23	0.2004288	0.0615671	0.0036251

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.77101	21	0.0383367
Inverse variance weighted	36.43305	22	0.0272736

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0092575	0.0071953	0.2122365

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017913	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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