Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 ptr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3787612	0.1051010	0.0016685
Weighted median	23	0.2338279	0.0585335	0.0000648
Inverse variance weighted	23	0.1997537	0.0432784	0.0000039
Simple mode	23	0.2036338	0.0860709	0.0272158
Weighted mode	23	0.2305416	0.0669580	0.0023198

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.01997	21	0.3429148
Inverse variance weighted	26.77311	22	0.2199709

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0109921	0.0059406	0.0783833

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015968	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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