Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 ml r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0960332	0.1019573	0.3569562
Weighted median	23	0.0830404	0.0572602	0.1469944
Inverse variance weighted	23	0.0756974	0.0392327	0.0536758
Simple mode	23	0.0466960	0.0925577	0.6189208
Weighted mode	23	0.0760024	0.0663226	0.2641279

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.66183	21	0.4192164
Inverse variance weighted	21.71026	22	0.4772921

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012487	0.0057628	0.8305434

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007707	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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