Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 ml l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0067767	0.1334020	0.9599659
Weighted median	23	0.0633540	0.0595094	0.2870541
Inverse variance weighted	23	0.0737362	0.0514549	0.1518509
Simple mode	23	0.1682065	0.1064901	0.1284815
Weighted mode	23	0.0792138	0.0692629	0.2650537

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.08363	21	0.0164658
Inverse variance weighted	37.84281	22	0.0190798

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049439	0.0075401	0.519149

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012537	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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