Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 mcp

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1457931	0.1357832	0.2951320
Weighted median	23	0.0546559	0.0660718	0.4081124
Inverse variance weighted	23	0.0688372	0.0523122	0.1882105
Simple mode	23	0.0349140	0.1356782	0.7993159
Weighted mode	23	0.0677930	0.1013628	0.5105710

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.42184	21	0.0114968
Inverse variance weighted	39.11548	22	0.0136881

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047255	0.0076747	0.5446924

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012785	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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