Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 ilf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3045552	0.1507044	0.0562255
Weighted median	23	0.2451469	0.0563075	0.0000134
Inverse variance weighted	23	0.2948862	0.0575487	0.0000003
Simple mode	23	0.2201401	0.0856762	0.0174878
Weighted mode	23	0.2240552	0.0551329	0.0005161

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.33162	21	0.0008473
Inverse variance weighted	47.34257	22	0.0013239

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005937	0.0085182	0.9450901

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0031457	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8