Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 ilf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2303502	0.1600816	0.1649024
Weighted median	23	0.2246800	0.0604204	0.0002003
Inverse variance weighted	23	0.2961147	0.0614116	0.0000014
Simple mode	23	0.1687684	0.0969771	0.0957795
Weighted mode	23	0.1814137	0.0596098	0.0059631

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	53.40445	21	0.0001203
Inverse variance weighted	53.91102	22	0.0001693

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0040383	0.0090481	0.6599397

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.003359	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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