Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 ifo r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2272772	0.1598955	0.1698785
Weighted median	23	0.2031985	0.0597688	0.0006745
Inverse variance weighted	23	0.2789294	0.0612298	0.0000052
Simple mode	23	0.2027103	0.0876289	0.0304408
Weighted mode	23	0.1830204	0.0630457	0.0082487

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	53.27916	21	0.0001254
Inverse variance weighted	53.59164	22	0.0001877

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031717	0.0090376	0.7291246

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0031544	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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