Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 ifo l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3016923	0.1651104	0.0819147
Weighted median	23	0.1956941	0.0636751	0.0021169
Inverse variance weighted	23	0.2883132	0.0630538	0.0000048
Simple mode	23	0.1354416	0.0934284	0.1612539
Weighted mode	23	0.1694628	0.0653851	0.0166463

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	56.81267	21	3.83e-05
Inverse variance weighted	56.83364	22	6.49e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008215	0.0093324	0.9306854

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0033573	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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