Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 fmi

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2445654	0.1636451	0.1499241
Weighted median	23	0.1483156	0.0626877	0.0179841
Inverse variance weighted	23	0.2342051	0.0624901	0.0001783
Simple mode	23	0.1255391	0.0980245	0.2136399
Weighted mode	23	0.1483952	0.0634759	0.0288950

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	55.80740	21	5.39e-05
Inverse variance weighted	55.81997	22	9.07e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006362	0.0092495	0.9458162

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0027705	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8