Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 fma

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0019351	0.1389820	0.9890223
Weighted median	23	0.0285636	0.0598277	0.6330553
Inverse variance weighted	23	0.1367835	0.0545313	0.0121297
Simple mode	23	-0.0089984	0.0988479	0.9282905
Weighted mode	23	-0.0089984	0.0614783	0.8849648

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.25026	21	0.0069325
Inverse variance weighted	42.50387	22	0.0054285

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0085179	0.0078554	0.2905073

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016559	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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