Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 cst r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2202851	0.1139363	0.0667806
Weighted median	23	0.1059054	0.0562709	0.0598276
Inverse variance weighted	23	0.1387541	0.0441255	0.0016635
Simple mode	23	0.1288151	0.0972546	0.1989277
Weighted mode	23	0.1114550	0.0635029	0.0931571

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.05154	21	0.1691536
Inverse variance weighted	27.83007	22	0.1813814

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0050064	0.0064399	0.4455864

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012222	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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