Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 cst l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1940592	0.1345441	0.1639543
Weighted median	23	0.1488164	0.0562373	0.0081397
Inverse variance weighted	23	0.2096021	0.0513920	0.0000453
Simple mode	23	0.1048760	0.0873356	0.2425840
Weighted mode	23	0.1222412	0.0621355	0.0618804

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.72376	21	0.0138829
Inverse variance weighted	37.75205	22	0.0195305

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009544	0.0076047	0.9013185

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0020086	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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