Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 cgh r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1315904	0.1067039	0.2311167
Weighted median	23	0.1755842	0.0580770	0.0025003
Inverse variance weighted	23	0.1659739	0.0408617	0.0000487
Simple mode	23	0.1830412	0.1008907	0.0833012
Weighted mode	23	0.1996173	0.0678646	0.0075509

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.72759	21	0.3064440
Inverse variance weighted	23.86606	22	0.3542895

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021113	0.0060311	0.7297693

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012655	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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