Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 cgh l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2049481	0.1003854	0.0539528
Weighted median	23	0.1768189	0.0539005	0.0010364
Inverse variance weighted	23	0.1248733	0.0392322	0.0014579
Simple mode	23	0.1553633	0.0874581	0.0894948
Weighted mode	23	0.1752795	0.0661226	0.0145995

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.44646	21	0.8496691
Inverse variance weighted	15.19745	22	0.8536261

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004917	0.005674	0.3959579

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007675	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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