Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 cgc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1993449	0.1380536	0.1635024
Weighted median	23	0.1548805	0.0623569	0.0129997
Inverse variance weighted	23	0.1311395	0.0530730	0.0134763
Simple mode	23	0.0515808	0.1207334	0.6733649
Weighted mode	23	0.1077767	0.0920070	0.2539707

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.71716	21	0.0080481
Inverse variance weighted	40.26202	22	0.0100742

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041882	0.0078031	0.5970905

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015584	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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