Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 cgc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1108082	0.1178076	0.3576112
Weighted median	23	0.1382411	0.0587222	0.0185650
Inverse variance weighted	23	0.1521852	0.0451379	0.0007474
Simple mode	23	0.1254768	0.1035299	0.2383741
Weighted mode	23	0.1294219	0.0740612	0.0944966

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.92135	21	0.1159027
Inverse variance weighted	29.12186	22	0.1414143

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0025408	0.0066587	0.7066129

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013384	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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