Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 atr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3324860	0.1372905	0.0245807
Weighted median	23	0.1608450	0.0565032	0.0044181
Inverse variance weighted	23	0.2055129	0.0536663	0.0001284
Simple mode	23	0.1088133	0.0864261	0.2212145
Weighted mode	23	0.1534844	0.0672215	0.0324348

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.27988	21	0.0090864
Inverse variance weighted	41.16819	22	0.0078694

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0077969	0.00776	0.3264518

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0020784	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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