Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 atr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2772155	0.1224182	0.0342493
Weighted median	23	0.2098775	0.0583435	0.0003216
Inverse variance weighted	23	0.2113466	0.0471211	0.0000073
Simple mode	23	0.2191380	0.0959404	0.0323771
Weighted mode	23	0.2191380	0.0714721	0.0056559

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.23043	21	0.0699075
Inverse variance weighted	31.73860	22	0.0819631

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0040447	0.0069194	0.5650757

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018407	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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