Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L2 ar l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1615275	0.1414678	0.2663914
Weighted median	23	0.1566938	0.0618832	0.0113385
Inverse variance weighted	23	0.1840984	0.0540549	0.0006598
Simple mode	23	0.2594243	0.1282813	0.0554689
Weighted mode	23	0.1248427	0.0689100	0.0837105

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.70559	21	0.0045811
Inverse variance weighted	41.76526	22	0.0066728

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.001386	0.007996	0.8640495

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019326	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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