Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 unc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3130676	0.1332572	0.0286675
Weighted median	23	0.2578914	0.0571194	0.0000063
Inverse variance weighted	23	0.2572290	0.0511317	0.0000005
Simple mode	23	0.2404772	0.1094365	0.0388145
Weighted mode	23	0.2488989	0.0630929	0.0006897

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.00837	21	0.0167969
Inverse variance weighted	37.37359	22	0.0215164

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034288	0.0075321	0.6536132

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0024348	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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