Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 unc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2420382	0.1337218	0.0846291
Weighted median	23	0.2178759	0.0567326	0.0001228
Inverse variance weighted	23	0.2354829	0.0510616	0.0000040
Simple mode	23	0.2099405	0.0848925	0.0216009
Weighted mode	23	0.2099405	0.0643700	0.0035739

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.26417	21	0.0156957
Inverse variance weighted	37.26921	22	0.0220957

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0004025	0.0075582	0.9580302

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0022207	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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