Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 str r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2163066	0.1223180	0.0915205
Weighted median	23	0.1360982	0.0567345	0.0164462
Inverse variance weighted	23	0.1643844	0.0469403	0.0004618
Simple mode	23	0.1220800	0.0876314	0.1775051
Weighted mode	23	0.1346312	0.0600166	0.0352798

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.17940	21	0.0707236
Inverse variance weighted	31.49516	22	0.0864196

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031883	0.0069137	0.6494231

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014861	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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