Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 str l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1491913	0.1226288	0.2372508
Weighted median	23	0.1426285	0.0543016	0.0086243
Inverse variance weighted	23	0.1402086	0.0468302	0.0027536
Simple mode	23	0.0656869	0.1027363	0.5291820
Weighted mode	23	0.1464763	0.0644616	0.0331920

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.33761	21	0.0682199
Inverse variance weighted	31.34706	22	0.0892295

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005516	0.0069312	0.937325

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013368	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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