Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 slf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2494846	0.1512338	0.1138913
Weighted median	23	0.1471290	0.0550340	0.0075082
Inverse variance weighted	23	0.2410719	0.0577492	0.0000299
Simple mode	23	0.1832952	0.0858628	0.0441695
Weighted mode	23	0.1401368	0.0578578	0.0241205

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.66218	21	0.0007643
Inverse variance weighted	47.67047	22	0.0011991

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0005166	0.008548	0.9523818

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0025876	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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