Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 slf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1791891	0.1385300	0.2098846
Weighted median	23	0.1648248	0.0573445	0.0040493
Inverse variance weighted	23	0.2407203	0.0531864	0.0000060
Simple mode	23	0.1922017	0.0868780	0.0376309
Weighted mode	23	0.1644416	0.0613736	0.0136980

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.99187	21	0.0074537
Inverse variance weighted	40.43531	22	0.0096125

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037783	0.00783	0.6344087

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0023654	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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