Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 ptr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2345055	0.1262993	0.0774317
Weighted median	23	0.1532077	0.0552939	0.0055921
Inverse variance weighted	23	0.2069746	0.0482887	0.0000182
Simple mode	23	0.1160723	0.1039616	0.2762579
Weighted mode	23	0.1515727	0.0647030	0.0286031

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.24125	21	0.0436095
Inverse variance weighted	33.33003	22	0.0573799

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016905	0.0071386	0.8150947

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018532	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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