Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 ptr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2082006	0.1160287	0.0871618
Weighted median	23	0.2354654	0.0609911	0.0001131
Inverse variance weighted	23	0.2174454	0.0443105	0.0000009
Simple mode	23	0.2796592	0.1043345	0.0136657
Weighted mode	23	0.2257989	0.0725232	0.0050631

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.05510	21	0.1385956
Inverse variance weighted	28.06511	22	0.1735336

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005677	0.0065582	0.9318408

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017812	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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