Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 ml r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0530652	0.1259135	0.6777150
Weighted median	23	-0.0673436	0.0608661	0.2685438
Inverse variance weighted	23	0.0400116	0.0480923	0.4054225
Simple mode	23	-0.1169442	0.1099660	0.2991087
Weighted mode	23	-0.0736097	0.0958899	0.4508578

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.03857	21	0.0457912
Inverse variance weighted	33.05852	22	0.0610553

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008016	0.0071168	0.9113948

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010332	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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