Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 ml l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0215840	0.1516921	0.8882087
Weighted median	23	0.0205366	0.0682602	0.7635234
Inverse variance weighted	23	0.0286732	0.0580991	0.6216439
Simple mode	23	0.0397672	0.1107564	0.7229799
Weighted mode	23	0.0656627	0.0996501	0.5167769

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.95231	21	0.0006980
Inverse variance weighted	48.24814	22	0.0010061

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.003086	0.0085738	0.7224893

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014778	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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