Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 mcp

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1741260	0.1179890	0.1548402
Weighted median	23	0.0819525	0.0624003	0.1890701
Inverse variance weighted	23	0.0340164	0.0468029	0.4673483
Simple mode	23	0.0257428	0.1267704	0.8409499
Weighted mode	23	0.1521710	0.0890360	0.1015043

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.01101	21	0.1137375
Inverse variance weighted	31.31021	22	0.0899403

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0086035	0.0066689	0.2110482

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009715	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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