Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 ilf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2295600	0.1662004	0.1817317
Weighted median	23	0.2575979	0.0590466	0.0000129
Inverse variance weighted	23	0.2844422	0.0636529	0.0000079
Simple mode	23	0.2636564	0.1033871	0.0182455
Weighted mode	23	0.2132244	0.0669297	0.0042726

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	57.56512	21	2.96e-05
Inverse variance weighted	57.91791	22	4.52e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.00337	0.0093939	0.7233663

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.003347	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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