Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 ilf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1780387	0.1435876	0.2286779
Weighted median	23	0.2440503	0.0608172	0.0000600
Inverse variance weighted	23	0.3028033	0.0559761	0.0000001
Simple mode	23	0.1788466	0.1123362	0.1256378
Weighted mode	23	0.1994338	0.0649978	0.0056262

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	42.96639	21	0.0031746
Inverse variance weighted	44.78960	22	0.0028218

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0076612	0.0081158	0.3559138

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0031619	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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