Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 ifo r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1165989	0.1607791	0.4763265
Weighted median	23	0.1454072	0.0623258	0.0196472
Inverse variance weighted	23	0.2571518	0.0626930	0.0000410
Simple mode	23	0.0867106	0.1128779	0.4505475
Weighted mode	23	0.1199408	0.0693608	0.0977768

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	53.86964	21	0.0001031
Inverse variance weighted	56.18342	22	0.0000805

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086306	0.0090875	0.3530537

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0030035	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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