Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 ifo l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1398660	0.1462117	0.3496534
Weighted median	23	0.1351351	0.0614955	0.0279864
Inverse variance weighted	23	0.2488855	0.0566921	0.0000113
Simple mode	23	0.0975162	0.0891821	0.2860250
Weighted mode	23	0.1437190	0.0577830	0.0209431

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.54932	21	0.0019838
Inverse variance weighted	45.94133	22	0.0020122

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066943	0.0082641	0.4269967

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0026111	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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