Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L1 fmi

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1373864	0.1279311	0.2950489
Weighted median	23	0.0852683	0.0598586	0.1543036
Inverse variance weighted	23	0.1256499	0.0488588	0.0101202
Simple mode	23	0.1580056	0.1026067	0.1378419
Weighted mode	23	0.0778427	0.0705457	0.2817620

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.10507	21	0.0353118
Inverse variance weighted	34.12120	22	0.0477478

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0007207	0.0072309	0.9215538

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013445	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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